In this issue, we look at six new migraine drugs and how to decide if they should be part of your own prevention strategy. We introduce you to a wand that can make wine's migraine triggers vanish. And we link you to the NIH website with the latest facts on the safety and effectiveness of specific herbal and nutritional supplements -- including those used for migraine.

There's so much happening right now in the migraine field! Keep up with us on Facebook for the latest news, research and helpful tips: Petadolex®, Dolovent™ and MIG-99®.

Tina Sanders

Linpharma Customer Education



New Migraine Drugs: A Look at What's Coming

“Migraine is really more than one disease,” says Dr. Richard Lipton, a leading neurologist and migraine researcher. “The reason one person responds to treatment and not another may be due to fundamental biological differences we have not yet discovered.” But what researchers have discovered is a handful of new drugs that work in new ways to stop migraines before they start.

Let’s look at a few of these new drugs and how they work:

  • Erenumab (Aimovig) is now available. This monthly injection belongs to a new class of drugs (monoclonal antibodies) that block calcitonin gene-related peptides. CGRPs are substances in the body that cause blood vessel activity in the brain thought to trigger migraines. Blocking this activity can “dial down the intensity” of these triggers to prevent a full-blown migraine attack.
  • Fremanezumab, galcanezumab and eptinezumab (given by IV) are migraine preventatives that also target CGRP activity. They are all heading toward FDA approval.
  • Rimegepant (taken orally) is another CGRP receptor “antagonist.” Clinical trials have shown a single dose can be effective at stopping a migraine, without any rescue medications. It’s awaiting FDA approval.
  • Ubrogepant (taken orally) is a selective oral calcitonin gene-related peptide (CGRP) receptor antagonist now in the last stage of clinical trials for acute treatment of migraines. Because migraine is a spectrum disease that’s different for everyone, none of these drugs will be the “silver bullet” for every migraine sufferer. The good news is that research continues to open up new options—especially for people who suffer the most chronic and intense migraines.
As these new drugs come onto the market, you want to assess if they’re an option for where you are in the migraine spectrum. The goal isn’t to go with what’s new but to find the best way to reduce migraine frequency and severity with the least impact from bothersome side effects and serious long-term risks. That’s why doctors view the new drugs as alternatives primarily for people who suffer chronic and severe migraines for which other treatments don’t work (or have stopped working). You may find that your own prevention strategy works best with natural alternatives, so there’s no need to add drugs that may have potentially serious health risks.

Safest migraine control strategy: Go with the least required, not the maximum available.

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Wine is always on the list of migraine triggers. That’s because it contains sulfites and histamine-rich tannins. Sometimes, even a small amount of wine can cause your brain’s blood vessels to spasm, setting off a chain reaction that results in anything from a dull headache or bad hangover to a full-blown migraine attack. But there may be a way to enjoy your wine without the pain.

Readers have told us about a product that can make all the difference: It’s The Wand. You swirl this little gadget in a glass of red or white wine and it absorbs both sulfites and histamines. Works with beer, too. You can find The Wand online and at Bed, Bath & Beyond and other stores. Let us know if it works for you!
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From NIH: Fact Sheets on Migraine-related Supplements

Want to learn more about the value—and safety—of specific herbal and dietary supplements? The National Institutes of Health offers fact sheets showing what’s known about each type of supplement and any precautions that apply.

This is a great source of independent information! You can find facts on key migraine-related supplements such as butterbur, feverfew, magnesium, riboflavin and CoQ10. From an alphabetized list, select the herb or nutrient you want to explore. A short summary appears. Click again on the name to see the full fact sheet.

Check out NIH supplement factsheets now.

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nutritional supplement

All-in-one, clinical strength supplement for correcting Magnesium, B2 and CoQ10 deficiencies associated with neurological discomfort.
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