The new Aimovig injection offers hope for otherwise hopeless migraines—ones so chronic and severe that nothing else helps. But this—and other CGRP-focused drugs coming soon—come with some serious concerns. In this issue we look at how to weigh the risks vs. rewards of these new options. We also look at how the vitamin deficiencies associated with migraines are different between men and women. And, we see why “mild” herbal and dietary preventatives can outperform “strong” prescription drugs.

Keep up with our latest prevention tips and news on Facebook: Petadolex and Dolovent. And please share your own tips for keeping migraines to a minimum.

Tina Sanders

Linpharma Customer Education



RISK ALERT: Long-Term Use of CGRP Drugs

Earlier this summer, the FDA approved Aimovig, an injectable drug designed to stop migraines before they start by targeting calcitonin gene-related peptides (CGRPs). Like three additional drugs now in the pipeline, Aimovig represents an important step forward in migraine research. As with any new drug, however, concerns exist about possible long-term effects.

Quoted on WebMD, Dr. Elizabeth Loder cautions that research shows these medications don’t work for everybody. Loder is a professor of neurology at Harvard Medical School and chief of the Division of Headaches at Brigham & Women’s Hospital.

CGRP receptors are found in the brain and the kidneys, pancreas, adrenal glands and bones. Since the drugs have only been studied for a few years, she says it’s hard to know the long-term effects. Right now, however, Loder notes there is clear concern “that [drugs that block CGRP activity] might cause high blood pressure in people who take them for long periods of time.”

Know the risks vs. rewards
Aimovig doesn’t work for everyone, but if you suffer severe, chronic migraines and other treatments don’t work—or have stopped working—this new drug may be worth investigating. As with any treatment you consider for migraine, make sure you fully understand the benefits and the potential downside. For example:

  • In talking with your doctor, be sure to discuss possible impact on your blood pressure.
  • Know that monthly injections can cost upwards of $8,000 a year. Make sure you know what insurance will cover and what co-pays apply.
  • Monitor what happens as patients use Aimovig for longer than the timeframe studied in the clinical trial. An easy way to do this is to subscribe to the FDA’s MedWatch Safety Alerts for emails about any problems that crop up with Aimovig (or any other drug you use). To get FDA Safety Alerts, CLICK HERE.

(back to the top)




What’s easier to take: Prescription propranolol or herbal MIG-99?

Here’s an example showing the “compliance rate” between propranolol and MIG-99®:

  • 17% of study participants using propranolol were able to stick with their regimen.
  • 93% of participants using MIG-99® completed the entire course of the study.
The takeaway: Not every preventative works for everyone. But without consistent use, no product works. You may not have to choose between suffering from migraines and suffering from drug side effects. Herbal and nutritional options may help you eliminate both.

(back to the top)

Men vs. Women: Different Nutrient Deficiencies Linked to Migraines

Research presented at the Annual Scientific Meeting of the American Headache Society adds to the evidence that nutrient deficiencies play a role in migraines. The research looked at vitamin D, riboflavin and coenzyme 10 (folate was also studied, but no link was found). What’s especially interesting is that this research points to a gender difference in terms of which deficiencies seem to trigger migraines:

  • Women were more likely to be deficient in CoQ10, which is found in meat, fish, nuts and some fruits and vegetables.
  • Men were more likely be deficient in vitamin D, a vitamin the body makes when exposed to the sun.
  • Both men and women who suffered chronic migraines were more likely to be deficient in both CoQ10 and riboflavin (vitamin B2) than those who suffered episodic migraines.
The takeaway: This research supports the value of a blended approach to dietary supplementation. Dolovent™, for instance, contains both CoQ10 and riboflavin. It also contains magnesium to correct common deficiencies long-associated with migraine sufferers.

(back to the top)

nutritional supplement

All-in-one, clinical strength supplement for correcting Magnesium, B2 and CoQ10 deficiencies associated with neurological discomfort.
Let us know what you think about the Natural Migraine Prevention Report newsletter, our products, and topics you'd like us to cover in upcoming issues.

Email Your Thoughts
herbal supplement

Petasites butterbur extract manufactured in Germany and PA-free.
Courtesy of Linpharma, Inc.
630 Brooker Creek Blvd., Suite 350, Oldsmar, FL 34677
Tel. 888-301-1084 (Mon.-Fri. 9 am to 5 pm EST)